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Phase I study of CBM.CD19 chimeric antigen receptor T cell in the treatment of refractory diffuse large B-cell lymphoma in Chinese patients

Frontiers of Medicine 2022, Volume 16, Issue 2,   Pages 285-294 doi: 10.1007/s11684-021-0843-8

Abstract: A single-center phase I dose-escalation study was conducted to evaluate the safety and efficacy of TNeurotoxicity or other dose-limiting toxicities was not observed in any dose cohort of C-CAR011 therapyAntitumor efficacy was apparent across dose cohorts.

Keywords： CAR-T cell therapy     refractory diffuse large B-cell lymphoma     cytokine release syndrome     dose-limitingtoxicity    

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Low-dose CT for lung cancer screening: opportunities and challenges

Hongbing Shen

Frontiers of Medicine 2018, Volume 12, Issue 1,   Pages 116-121 doi: 10.1007/s11684-017-0600-1

Abstract: However, minimal progress was achieved until recently, when low-dose spiral computed tomography (LDCT

Keywords： lung cancer     low-dose computerized tomography     early detection     opportunities     challenges    

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Estimation of the minimum effective dose of tramadol for postoperative analgesia in infants using the

Yue’e Dai, Dongxu Lei, Zhenghua Huang, Yan Yin, G. Allen Finley, Yunxia Zuo

Frontiers of Medicine 2012, Volume 6, Issue 3,   Pages 288-295 doi: 10.1007/s11684-012-0208-4

Abstract: In each phase, 24 participants were allocated a different tramadol dose.In phase 1, seven dose levels were used within the range 0.1–0.4 mg?Phase 1 was insufficient to identify the MED, and we increased the dose to 0.4–0.8 mg?In phase 2, it was 84.7% (95% CI, 0.789–0.991) with the dose 0.8 mg?kg-1?In phase 3, the successful analgesia probability for dose 0.35 mg?kg-1?

Keywords： tramadol     minimum effective dose     postoperative analgesia     infants     continual reassessment method    

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Comparison of exogenous degrader-enhanced bioremediation with low-dose persulfate oxidation for polycyclic

Frontiers of Environmental Science & Engineering 2023, Volume 17, Issue 11, doi: 10.1007/s11783-023-1733-x

Abstract: In this study, bioaugmentation with a PAH-degrading Bacillus PheN7 (BA) and low-dose persulfate

Keywords： Bioaugmentation     Low-dose persulfate oxidation     Polycyclic aromatic hydrocarbon     Remediation    

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Collapse fragility assessment of steel roof framings with force limiting devices under transient wind

Linjia BAI, Yunfeng ZHANG

Frontiers of Structural and Civil Engineering 2012, Volume 6, Issue 3,   Pages 199-209 doi: 10.1007/s11709-012-0168-4

Abstract: example based on a Steel Joist Institute (SJI) K series joist was used to demonstrate the use of force limiting

Keywords： collapse     dynamic response     fragility analysis     Monte Carlo simulation     wind load    

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Early assessment of the safety and immunogenicity of a third dose (booster) of COVID-19 immunization

Frontiers of Medicine 2022, Volume 16, Issue 1,   Pages 93-101 doi: 10.1007/s11684-021-0914-x

Abstract: Here we report a pilot open-label trial of a third dose of BBIBP-CorV, an inactivated SARS-CoV-2 vaccinein all participants within 4 weeks, surpassing the peak antibody titers elicited by the initial two-dose

Keywords： COVID-19     SARS-CoV-2     vaccine     immunization     booster immunization    

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Reproductive toxicity study with a novel deoxyguanosine analogue (Metacavir) in pregnant SD rats

Qihui Luo,Zhengli Chen,Anchun Cheng,Mingshu Wang,Jing Fang,Xi Peng,Li Tang

Frontiers of Medicine 2015, Volume 9, Issue 1,   Pages 82-89 doi: 10.1007/s11684-015-0376-0

Abstract: In this study, the maternal toxicity, embryo-fetal developmental toxicity and teratogenicity were studiedSlower weight gain was observed in 5 out of 21 rats subjected to a 200 mg/kg dose, as well as 2 out of20 subjected to a 100 mg/kg dose.The present research indicated that at a dose of 200 mg/(kg·d) (i.e., 40 times the effective dosein rats), Metacavir shows some maternal toxicity to SD rats.

Keywords： deoxyguanosine analogue     Metacavir     pregnancy     maternal toxicity     embryo toxicity     teratogenicity    

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Interaction and combined toxicity of microplastics and per- and polyfluoroalkyl substances in aquatic

Frontiers of Environmental Science & Engineering 2022, Volume 16, Issue 10, doi: 10.1007/s11783-022-1571-2

Abstract:

● Adsorption of PFASs on MPs and its mechanisms are critically reviewed.

Keywords： Microplastics     Per- and Polyfluoroalkyl substances     Adsorption     Transport     Transformation    

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Product identification and toxicity change during oxidation of methotrexate by ferrate and permanganate

Frontiers of Environmental Science & Engineering 2022, Volume 16, Issue 7, doi: 10.1007/s11783-021-1501-8

Abstract:

• Oxidation of methotrexate by high-valent metal-oxo species was first explored.

Keywords： Anticancer drugs     High-valent metal-oxo species     Oxidation kinetics     Reaction mechanisms     Multi-endpoint toxicity    

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Evaluation of soil microbial toxicity of waste foundry sand for soil-related reuse

Haifeng ZHANG, Lu SU, Xiangyu LI, Jiane ZUO, Guangli LIU, Yujue WANG

Frontiers of Environmental Science & Engineering 2014, Volume 8, Issue 1,   Pages 89-98 doi: 10.1007/s11783-013-0591-3

Abstract: The relationship between the chemical contaminants and soil microbial toxicity of waste foundry sandThe soil microbial toxicity of each WFS was evaluated by measuring the dehydrogenase activity (DHA) of, the WFSs with higher concentrations of metal and organic contaminants exhibited greater microbial toxicity

Keywords： waste foundry sand     toxicity     bioassay     soil microbial activity     waste reuse    

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ROUTE DEVELOPMENT, ANTIVIRAL STUDIES, FIELD EVALUATION AND TOXICITY OF AN ANTIVIRAL PLANT PROTECTANT

Frontiers of Agricultural Science and Engineering 2022, Volume 9, Issue 1, doi: 10.15302/J-FASE- 2021390

Abstract: permitting further assessment of its antivirus activity in the greenhouse and field experiments, and toxicityThe toxicity tests showed that NK0238 was not acutely toxic to birds, fish, honey bees and silkworms.optimized route provides a solid foundation for its large-scale synthesis and subsequent efficacy and toxicity

Keywords： protectant / antiviral in the greenhouse / field evaluation / l-trp-NCA / synthesis optimization / toxicity    

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An investigation on patient dose in screen-film diagnostic radiology in Lhasa City, Xizang Autonomous

Xiang Du

Frontiers of Medicine 2013, Volume 7, Issue 4,   Pages 506-509 doi: 10.1007/s11684-013-0294-y

Abstract:

This study aimed to investigate patient dose in diagnostic screen-film radiographic examinations in

Keywords： radiation dosage     radiology     radiation protection     radiography/statistics & numerical data    

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Understanding the role of nano-TiO on the toxicity of Pb on through modeling–Is it additive or synergistic

Frontiers of Environmental Science & Engineering 2022, Volume 16, Issue 5, doi: 10.1007/s11783-021-1493-4

Abstract: ItemContent>

• A two-compartment model is able to quantify the effect of nano-TiO2 on Pb toxicity

Keywords： Algae     C. dubia     Lead     Nano-TiO2     Synergistic toxicity     Two-compartment toxicokinetic-toxicodynamic    

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Toxicity models of metal mixtures established on the basis of “additivity” and “interactions”

Yang Liu,Martina G. Vijver,Bo Pan,Willie J. G. M. Peijnenburg

Frontiers of Environmental Science & Engineering 2017, Volume 11, Issue 2, doi: 10.1007/s11783-017-0916-8

Abstract: · No preference is set between CA and IA models to assess toxicity of metal mixtures. · Increased modelThis review summarizes the existing predictive tools for evaluating the combined toxicity of metals presentbackground information on how to make good use of the tools and how to advance the methods for assessing toxicityTo improve the reliability of toxicity modeling for metal mixtures, further efforts should focus on balancingrelationship between the significance of statistics and the biological meaning, and unraveling the toxicity

Keywords： Metal     Mixtures     Toxicity     Additivity     Modeling     Interactions    

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Leaching toxicity characteristics of municipal solid waste incineration bottom ash

Khamphe PHOUNGTHONG,Yi XIA,Hua ZHANG,Liming SHAO,Pinjing HE

Frontiers of Environmental Science & Engineering 2016, Volume 10, Issue 2,   Pages 399-411 doi: 10.1007/s11783-015-0819-5

Abstract: and hierarchical cluster analysis, were used to evaluate the contributions of the constituents to the toxicity

Keywords： Municipal solid waste incineration     bottom ash     alternative material     leaching tests     toxicity     Vibrio    

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Title Author Date Type Operation

Phase I study of CBM.CD19 chimeric antigen receptor T cell in the treatment of refractory diffuse large B-cell lymphoma in Chinese patients

Journal Article

Low-dose CT for lung cancer screening: opportunities and challenges

Hongbing Shen

Journal Article

Estimation of the minimum effective dose of tramadol for postoperative analgesia in infants using the

Yue’e Dai, Dongxu Lei, Zhenghua Huang, Yan Yin, G. Allen Finley, Yunxia Zuo

Journal Article

Comparison of exogenous degrader-enhanced bioremediation with low-dose persulfate oxidation for polycyclic

Journal Article

Collapse fragility assessment of steel roof framings with force limiting devices under transient wind

Linjia BAI, Yunfeng ZHANG

Journal Article

Early assessment of the safety and immunogenicity of a third dose (booster) of COVID-19 immunization

Journal Article

Reproductive toxicity study with a novel deoxyguanosine analogue (Metacavir) in pregnant SD rats

Qihui Luo,Zhengli Chen,Anchun Cheng,Mingshu Wang,Jing Fang,Xi Peng,Li Tang

Journal Article

Interaction and combined toxicity of microplastics and per- and polyfluoroalkyl substances in aquatic

Journal Article

Product identification and toxicity change during oxidation of methotrexate by ferrate and permanganate

Journal Article

Evaluation of soil microbial toxicity of waste foundry sand for soil-related reuse

Haifeng ZHANG, Lu SU, Xiangyu LI, Jiane ZUO, Guangli LIU, Yujue WANG

Journal Article

ROUTE DEVELOPMENT, ANTIVIRAL STUDIES, FIELD EVALUATION AND TOXICITY OF AN ANTIVIRAL PLANT PROTECTANT

Journal Article

An investigation on patient dose in screen-film diagnostic radiology in Lhasa City, Xizang Autonomous

Xiang Du

Journal Article

Understanding the role of nano-TiO on the toxicity of Pb on through modeling–Is it additive or synergistic

Journal Article

Toxicity models of metal mixtures established on the basis of “additivity” and “interactions”

Yang Liu,Martina G. Vijver,Bo Pan,Willie J. G. M. Peijnenburg

Journal Article

Leaching toxicity characteristics of municipal solid waste incineration bottom ash

Khamphe PHOUNGTHONG,Yi XIA,Hua ZHANG,Liming SHAO,Pinjing HE

Journal Article